Synthesis of Novel Cyclopropyl Nucleoside Analogues as Potential Antiherpetic Agent

Combinatorial synthesis of galactosyl-1,3,5-triazines as novel nucleoside analogues.

Herein we report a parallel solid-phase synthesis of 1,3,5-triazine based nucleoside analogues by a three-step substitution, starting from 2,4,6-trichloro-1,3,5-triazine. A library of 80 galactosyl-1,3,5-triazine compounds was prepared in high purity without extensive reaction conditions or tedious purification, suggesting the generality of this method.

Chemical Synthesis of Nucleoside Analogues Chemical Synthesis of Nucleoside Analogues

Synthesis and HPLC-Analysis of N-(2-Phenyl-cyclopropyl)-Substituted Chain Elongated Nucleoside Analogues

Rene Csuk, Anja Kern, and Kristina Mohr Institut für Organische Chemie. Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany Reprint requests to Prof. Dr. R. Csuk. E-mail: [email protected] Z. Naturforsch. 54b, 1463-1468 (1999); received July 9, 1999 Nucleoside Analogues, HPLC A novel class of nucleoside analogues containing adenine, uracil, thym...

Synthesis and Evaluation of Novel Triterpene Analogues of Ursolic Acid as Potential Antidiabetic Agent

Ursolic acid (UA) is a naturally bioactive compound that possesses potential anti-diabetic activity. The relatively safe and effective molecule intrigued us to further explore and to improve its anti-diabetic activity. In the present study, a series of novel UA analogues was synthesized and their structures were characterized. Their bioactivities against the α-glucosidase from baker's yeast wer...

Synthesis of some novel hydrazono acyclic nucleoside analogues

The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ether group was replaced with a hydrazone moiety using phenylhydrazine. To interpret the dominant formation of (E)-hydrazone derivatives rather tha...